I've not done enough digging on the issue I'm presently experiencing to draw any conclusions make any suggestions, but this change seems to break the present distribute module (version 0.6.27). It appears it will likely break a great deal of other code too.

I've pasted the relevant output here and attached the full traceback.
  File "/usr/lib64/python3.2/hashlib.py", line 112, in __get_openssl_constructor
    f(usedforsecurity=False)
TypeError: openssl_md5() takes no keyword arguments

Whilst I agree with the notion behind this change, Fedora's quick actions have led to me spending the best part of an hour of the night before ship day diagnosing issues caused by undocumented (or at least under-documented) changes to code I haven't written or interfaced with. _Please_ publicise the change a little better? Pretty please!?