The following exclusion criteria were applied: neurological disorder, psychiatric disorders other than major depressive disorder, history of malignancy, head trauma or stroke, drug abuse or addiction, metabolic or endocrine abnormalities, diabetes mellitus (even in the absence of retinopathy), intraocular pressure (IOP) >21 mmHg (even in the absence of glaucoma, presence of glaucoma), congenital color vision disorders, congenital optic nerve head anomalies, best corrected visual acuity (BCVA) <0.6, high ammetropy (sphere dpt >4 and cylinder dpt >2), optic media opacities that could bias functional or structural retinal testing such as cataract (nuclear sclerosis > Grade 2), central corneal opacities and OCT tests performed unreliably.
Other nitric oxide synthases, neuronal NOS (nNOS) and endothelial NOS (eNOS), did not change with exposure to nPM or had unreliably high CT values (see Figure S3), suggesting that iNOS was the major contributor to the nitrite induction.
In contrast, on the equatorial Andes there is little seasonality, with typical weather conditions comprising prolonged cloud cover and frequent rain, with only short and unreliably occurring sunny times.
From unreliably identifying birthmarks in the 1845 suit brought by Salome Muller, who claimed to be a free, German-born woman kidnapped into slavery; through an early use of a "disability con" in Herman Melville's 1857 novel, The Confidence Man: His Masquerade; to the use of fingerprinting to settle a case of racial misidentification in Mark Twain's Pudd'nhead Wilson (1894); to twentieth-century attempts to "biocertify" claims to Native American or Hawaiian identity through "blood quantum" measurements; and finally, to current debates over sex testing in sports, things always seems to get complicated.