Using real-time
uncoating measurements and high-resolution structures, a research team comprised of docent Varpu Marjomaki's group (Nanoscience Center at the University of Jyvaskyla) and professor Sarah Butcher's group (University of Helsinki) found that the common molecule in serum and interstitial fluids, albumin, and an ion composition that is typically developed in cellular vesicles, trigger expansion of the virion.
AB-423 exhibits a dual mode of action in C3AhNTCP cells, namely inhibition of encapsidation of pgRNA during ongoing infection in addition to inhibition of rcDNA-cccDNA synthesis, presumably via inhibition of the capsid
uncoating step.
Several receptors associated with virus binding, internalization, and
uncoating have been identified [8].
revealed that HD-5 blocked the
uncoating mechanism of the virus by stabilizing the capsid in BrdU-labeled HAdV-5 [20].
From there, the capsid disassembles through a process called "
uncoating," which is crucial to the synthesis of viral DNA from its RNA genome and the hijacking of the cell's functions.
Lou et al., "Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle
uncoating after fission," Neuron, vol.
As coat protein gene of PVX interferes with viral
uncoating, movement and translation (Fedorkin et al., 2001) thus a transgenic plant harboring resistance against CP gene, will be potentially more effective against invading PVX.